Title : Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein.

Pub. Date : 2006 Jun

PMID : 16571669






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 One mechanism for regulation of this metabolic interface involves oxysterol binding protein (OSBP) via high-affinity binding to oxysterol regulators of cholesterol homeostasis and activation of SM synthesis at the Golgi apparatus. Cholesterol LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus
2 One mechanism for regulation of this metabolic interface involves oxysterol binding protein (OSBP) via high-affinity binding to oxysterol regulators of cholesterol homeostasis and activation of SM synthesis at the Golgi apparatus. Cholesterol LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus
3 RNA interference (RNAi) experiments in Chinese hamster ovary (CHO)-K1 cells revealed that OSBP and vesicle-associated membrane protein-associated protein (VAP) were required for stimulation of CERT-dependent ceramide transport and SM synthesis by 25-hydroxycholesterol and cholesterol depletion in response to cyclodextrin. Cholesterol LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus