Pub. Date : 2006 Mar 27
PMID : 16566823
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of COX-2 is also found in an experimental model of PD produced by administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 2 | COX-2 deficiency attenuated MPTP-induced microglial activation, degeneration of TH-positive cells, and loss of coordination. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 3 | CONCLUSION: These results indicate that reducing COX-2 activity can mitigate the secondary and progressive loss of dopaminergic neurons as well as the motor deficits induced by MPTP, possibly by suppression of microglial activation in the SNpc. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |