Pub. Date : 2006 Aug
PMID : 16565789
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1. | Lycopene | cyclin D1 | Homo sapiens |
| 2 | We have previously demonstrated that slowdown of serum-stimulated cell cycle progression from G1 to S phase by lycopene correlates with reduction in cyclin D1 levels, suggesting that the expression of this protein is a main target for lycopene"s action. | Lycopene | cyclin D1 | Homo sapiens |
| 3 | AIM OF THE STUDY: To determine whether the reported reduction in cyclin D1 level is the key mechanism for lycopene and atRA inhibitory action on IGF-I-induced cell cycle progression. | Lycopene | cyclin D1 | Homo sapiens |
| 4 | Our results showed that ectopic expression of cyclin D1 can overcome cell cycle inhibition caused by lycopene and atRA. | Lycopene | cyclin D1 | Homo sapiens |