Title : Free radical-mediated neurotoxicity may be caused by inhibition of mitochondrial dehydrogenases in vitro and in vivo.

Pub. Date : 2006 Jun 19

PMID : 16563643






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Thiamine (6 mM), and dihydrolipoic acid (50 microM), required cofactors for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase (thiamine as thiamine pyrophosphate), attenuated the reactive oxygen species-induced reductions in these enzyme activities, as well as subsequent loss of mitochondrial transmembrane potential and ATP, and neuronal death. Thiamine Pyrophosphate oxoglutarate dehydrogenase Rattus norvegicus