Pub. Date : 2006 May 12
PMID : 16563352
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 2 | Resonance Raman data, reported for the first time for CYP2D6, show that the CYP2D6 heme is found to be in a six-coordinated low-spin state in the absence of substrates, and it is perturbed to different extents by bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine (MDMA). | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 3 | Resonance Raman data, reported for the first time for CYP2D6, show that the CYP2D6 heme is found to be in a six-coordinated low-spin state in the absence of substrates, and it is perturbed to different extents by bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine (MDMA). | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 4 | Resonance Raman data, reported for the first time for CYP2D6, show that the CYP2D6 heme is found to be in a six-coordinated low-spin state in the absence of substrates, and it is perturbed to different extents by bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine (MDMA). | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 5 | Resonance Raman data, reported for the first time for CYP2D6, show that the CYP2D6 heme is found to be in a six-coordinated low-spin state in the absence of substrates, and it is perturbed to different extents by bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine (MDMA). | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 6 | Dextromethorphan and MDMA induce in CYP2D6 a significant amount of five-coordinated high-spin heme species and reduce the polarity of its heme-pocket, whereas bufuralol does not. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 7 | Spectra of the F120A mutant CYP2D6 suggest that Phe120 is involved in substrate-binding of dextromethorphan and MDMA, being responsible for the spectral differences observed between these two compounds and bufuralol. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 8 | These differences could be explained postulating a different substrate mobility for each compound in the CYP2D6 active site, consistently with the role previously suggested for Phe120 in binding dextromethorphan and MDMA. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |