Pub. Date : 2006 Jun
PMID : 16551736
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interestingly, in Cushing"s disease, ghrelin markedly increases plasma ACTH, whereas its stimulatory action on GH secretion is reduced. | Ghrelin | proopiomelanocortin | Homo sapiens |
| 2 | Although the reported expression of ghrelin receptors (GHS-R) in corticotrope tumors offers a potential mechanism for ghrelin-induced ACTH hypersecretion, studies on the direct effects of synthetic GH secretagogues on corticotropinoma cells offered contradictory results. | Ghrelin | proopiomelanocortin | Homo sapiens |
| 3 | Importantly, double immunogold electron microscopy revealed that ghrelin is costored within ACTH secretory vesicles in densely granulated adenomatous corticotropes. | Ghrelin | proopiomelanocortin | Homo sapiens |
| 4 | Our findings provide a plausible cellular basis for the exaggerated ACTH response to ghrelin in Cushing"s disease and suggest novel research strategies to develop medical treatments for this disease. | Ghrelin | proopiomelanocortin | Homo sapiens |