Pub. Date : 2006 May 19
PMID : 16551622
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using oocytes, externally applied TEA blocked AQP1/AQP2/AQP4 with IC50 values of 1.4, 6.2, and 9.8 microM, respectively. | Tetraethylammonium | aquaporin 1 (Colton blood group) | Homo sapiens |
| 2 | TEA inhibition was lost upon a Tyr to Phe amino acid switch in the external water pore of AQP1/AQP2/AQP4, whereas the water permeability of AQP3 and AQP5, which lack a corresponding Tyr, was not blocked by TEA. | Tetraethylammonium | aquaporin 1 (Colton blood group) | Homo sapiens |
| 3 | TEA inhibition was lost upon a Tyr to Phe amino acid switch in the external water pore of AQP1/AQP2/AQP4, whereas the water permeability of AQP3 and AQP5, which lack a corresponding Tyr, was not blocked by TEA. | Tetraethylammonium | aquaporin 1 (Colton blood group) | Homo sapiens |
| 4 | Consistent with experimental data, multi-nanosecond molecular dynamics simulations showed one stable binding site for TEA, but not tetramethyl (TMA), in AQP1, resulting in a nearly 50% water permeability inhibition, which was reduced in AQP1-Y186F due to effects on the TEA inhibitory binding region. | Tetraethylammonium | aquaporin 1 (Colton blood group) | Homo sapiens |
| 5 | Consistent with experimental data, multi-nanosecond molecular dynamics simulations showed one stable binding site for TEA, but not tetramethyl (TMA), in AQP1, resulting in a nearly 50% water permeability inhibition, which was reduced in AQP1-Y186F due to effects on the TEA inhibitory binding region. | Tetraethylammonium | aquaporin 1 (Colton blood group) | Homo sapiens |
| 6 | Consistent with experimental data, multi-nanosecond molecular dynamics simulations showed one stable binding site for TEA, but not tetramethyl (TMA), in AQP1, resulting in a nearly 50% water permeability inhibition, which was reduced in AQP1-Y186F due to effects on the TEA inhibitory binding region. | Tetraethylammonium | aquaporin 1 (Colton blood group) | Homo sapiens |
| 7 | The loss of TEA inhibition in oocytes expressing properly folded AQP1-N42A or -T44A is in line with the computationally predicted binding mode. | Tetraethylammonium | aquaporin 1 (Colton blood group) | Homo sapiens |
| 8 | Our data reveal that the molecular interaction of TEA with AQP1 differs and is about 1000-fold more effective on AQPs than on potassium channels. | Tetraethylammonium | aquaporin 1 (Colton blood group) | Homo sapiens |