Pub. Date : 1991 Sep 1
PMID : 1654884
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A study of human erythrocyte acetylcholinesterase inhibition by chlorpromazine. | Chlorpromazine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Membrane-bound acetylcholinesterase (AChE) from the human erythrocyte is inhibited by chlorpromazine (CPZ) in a concentration range within this amphiphilic drug has been demonstrated to interact with erythrocyte membranes, causing a large spectrum of physical and structural effects; membrane solubilization with 0.5% Triton X-100 results in a complete loss of CPZ inhibitory potency. | Chlorpromazine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | Membrane-bound acetylcholinesterase (AChE) from the human erythrocyte is inhibited by chlorpromazine (CPZ) in a concentration range within this amphiphilic drug has been demonstrated to interact with erythrocyte membranes, causing a large spectrum of physical and structural effects; membrane solubilization with 0.5% Triton X-100 results in a complete loss of CPZ inhibitory potency. | Chlorpromazine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | Membrane-bound acetylcholinesterase (AChE) from the human erythrocyte is inhibited by chlorpromazine (CPZ) in a concentration range within this amphiphilic drug has been demonstrated to interact with erythrocyte membranes, causing a large spectrum of physical and structural effects; membrane solubilization with 0.5% Triton X-100 results in a complete loss of CPZ inhibitory potency. | Chlorpromazine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | Membrane-bound acetylcholinesterase (AChE) from the human erythrocyte is inhibited by chlorpromazine (CPZ) in a concentration range within this amphiphilic drug has been demonstrated to interact with erythrocyte membranes, causing a large spectrum of physical and structural effects; membrane solubilization with 0.5% Triton X-100 results in a complete loss of CPZ inhibitory potency. | Chlorpromazine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | These results demonstrate unequivocally that CPZ inhibits human erythrocyte AChE through direct molecular interaction. | Chlorpromazine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 7 | The inhibition kinetics displayed by CPZ on human erythrocyte AChE are dependent on drug concentration: evidence is provided that this phenomenon may be related to formation of CPZ micellar aggregates. | Chlorpromazine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 8 | The inhibition kinetics displayed by CPZ on human erythrocyte AChE are dependent on drug concentration: evidence is provided that this phenomenon may be related to formation of CPZ micellar aggregates. | Chlorpromazine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |