Title : Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia.

Pub. Date : 2006 Aug 1

PMID : 16543464






1 Functional Relationships(s)
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1 Combination treatment of Nutlin-3a and fludarabine synergistically increased p53 levels, and induced conformational change of Bax and apoptosis in wild-type p53 cells but not in cells with mutant p53. fludarabine BCL2 associated X, apoptosis regulator Homo sapiens