Title : The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth.

Pub. Date : 2006 Aug

PMID : 16541323






2 Functional Relationships(s)
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1 In this study we investigated the effect of a GH antagonist, pegvisomant (Somavert, Pfizer), on normal mammary gland development and breast cancer xenograft growth. pegvisomant growth hormone Mus musculus
2 This effect of pegvisomant was mediated by a complete inhibition of both GH and IGF-IR-mediated signaling within the gland. pegvisomant growth hormone Mus musculus