Pub. Date : 2006 Mar
PMID : 16538385
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We have previously shown that membrane-permeable cAMP and cGMP analogs attenuate tumor necrosis factor alpha plus actinomycin D (TNFalpha/ActD)-induced apoptosis in hepatocytes at a step upstream of caspase activation and cytochrome c release. | Cyclic AMP | caspase 2 | Homo sapiens |
2 | We show here that cyclic nucleotide analogs dibutyryl cAMP (db-cAMP) and 8-bromo-cGMP (Br-cGMP) inhibit cell death and the cleavages of multiple caspases including caspase-10, -9, -8, -3, and -2, as well as suppress FADD protein up-regulation in TNFalpha/ActD-induced apoptosis. | Cyclic AMP | caspase 2 | Homo sapiens |