Title : Efficient copper-free PdCl2(PCy3)2-catalyzed Sonogashira coupling of aryl chlorides with terminal alkynes.

Pub. Date : 2006 Mar 17

PMID : 16526813






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1 Efficient copper-free PdCl2(PCy3)2-catalyzed Sonogashira coupling of aryl chlorides with terminal alkynes. aryl chlorides phosducin like 2 Homo sapiens
2 Under copper-free conditions and with Cs2CO3 as a base, PdCl2(PCy3)2 showed high catalytic activity for cross-coupling of electron-rich, electron-neutral, and electron-deficient aryl chlorides with a variety of terminal alkynes in DMSO at 100-120 degrees C affording internal arylated alkynes in good to excellent yields. aryl chlorides phosducin like 2 Homo sapiens