Title : Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases.

Pub. Date : 2006 Mar 21

PMID : 16525558






1 Functional Relationships(s)
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1 Since the enantiomers of some pharmaceuticals have revealed surprising biological activities, the L-nucleoside analogues (+)-5 x HCl and (-)-6, respectively, of D-ImmH and D-DADMe-ImmH, were prepared and their PNPase binding properties were studied. l-nucleoside polyribonucleotide nucleotidyltransferase 1 Homo sapiens