Pub. Date : 2006 Mar
PMID : 16522461
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | G protein-coupled receptor 154 gene polymorphism is associated with airway hyperresponsiveness to methacholine in a Chinese population. | Methacholine Chloride | neuropeptide S receptor 1 | Homo sapiens |
| 2 | OBJECTIVE: To test the association between GPR154 gene polymorphisms and airway responsiveness to methacholine in a Chinese population. | Methacholine Chloride | neuropeptide S receptor 1 | Homo sapiens |
| 3 | RESULTS: In stage I, we found that airway hyperresponsiveness to methacholine was associated with 2 single SNPs, rs324981 and rs324987, but not with the haplotypes of GPR154. | Methacholine Chloride | neuropeptide S receptor 1 | Homo sapiens |
| 4 | CONCLUSIONS: Our study supports a role of the GPR154 gene in asthma susceptibility and suggests that the AA homozygote of rs324981 is a protective factor for airway hyperresponsiveness to methacholine in a Chinese population. | Methacholine Chloride | neuropeptide S receptor 1 | Homo sapiens |