Title : Dicoumarol potentiates cisplatin-induced apoptosis mediated by c-Jun N-terminal kinase in p53 wild-type urogenital cancer cell lines.

Pub. Date : 2006 Apr 20

PMID : 16518417






2 Functional Relationships(s)
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1 In RT112 and LNCap, CDDP induced p53 and p21 expression, while pretreatment of dicoumarol suppressed induction of p53/p21 and resulted in sequential activation of c-Jun N-terminal kinase (JNK) in a time-dependent manner. Dicumarol H3 histone pseudogene 16 Homo sapiens
2 These results suggested that dicoumarol could enhance cytotoxicity of CDDP in urogenital cancer cells with wild-type p53 through the p53/p21/JNK pathways. Dicumarol H3 histone pseudogene 16 Homo sapiens