Pub. Date : 2006 Jun
PMID : 16508789
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of the tyrosine phosphatase early gene of liver regeneration (PRL-1) in cell cycle and in liver regeneration and fibrosis effect of halofuginone. | halofuginone | protein tyrosine phosphatase 4A1 | Homo sapiens |
| 2 | In this study, we evaluated the effect of halofuginone on PRL-1 expression, its cellular localization in vitro and during liver regeneration, and fibrosis progression in vivo. | halofuginone | protein tyrosine phosphatase 4A1 | Homo sapiens |
| 3 | The halofuginone-dependent increase in PRL-1 gene expression was correlated with an increase in the transcription factor early growth response-1 (Egr-1) and inversely correlated with the inhibition of cell proliferation. | halofuginone | protein tyrosine phosphatase 4A1 | Homo sapiens |
| 4 | Halofuginone also affected the PRL-1 sub-cellular localization that was cell-cycle-dependent. | halofuginone | protein tyrosine phosphatase 4A1 | Homo sapiens |
| 5 | The regulation of the expression of the early genes of regeneration such as PRL-1 and IGFBP-1 is thus part of the mode of action of halofuginone and results in the prevention of liver fibrosis and improved cirrhotic liver regeneration. | halofuginone | protein tyrosine phosphatase 4A1 | Homo sapiens |