Pub. Date : 1991 Aug 5
PMID : 1650363
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of quinolone derivatives on eukaryotic topoisomerase II. | Quinolones | Topoisomerase 2 | Drosophila melanogaster |
| 2 | Although quinolone cross-resistance was less pronounced than observed for etoposide (approximately 12-fold), it indicates that topoisomerase II is a physiological target for CP-67,804 and CP-115,953 in mammalian cells. | Quinolones | Topoisomerase 2 | Drosophila melanogaster |
| 3 | These findings strongly suggest that these quinolone derivatives represent a novel class of topoisomerase II-targeted drugs which have potential as antineoplastic agents. | Quinolones | Topoisomerase 2 | Drosophila melanogaster |