Pub. Date : 2006 May
PMID : 16501006
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of CYP2A and CYP2E1 in the metabolism of 3-methylindole in primary cultured porcine hepatocytes. | Skatole | cytochrome P450 family 2 subfamily E member 1 | Sus scrofa |
| 2 | Treatment with general P450 inhibitors resulted in further decreases in CYP2E1 activity and a more dramatic decrease in the production of 3MI metabolites, suggesting that additional P450s may be involved in the phase 1 metabolism of 3-methylindole. | Skatole | cytochrome P450 family 2 subfamily E member 1 | Sus scrofa |
| 3 | In conclusion, CYP2E1 activity levels are more important than CYP2A activity levels for the metabolism of 3-methylindole in isolated pig hepatocytes. | Skatole | cytochrome P450 family 2 subfamily E member 1 | Sus scrofa |