Pub. Date : 2006 Mar 18
PMID : 16497293
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | But most interestingly, when cells were preincubated with 17-beta-estradiol, the ability of TGF-beta to evoke chemotaxis was drastically diminished. | Estradiol | transforming growth factor beta 1 | Homo sapiens |
| 2 | In agreement, pretreatment of MCF-7 cells with 17-beta-estradiol resulted in a reduced phosphorylation of Smad2 and Smad3 as well as a diminished Smad2 and Smad3 gene reporter activity in response to TGF-beta. | Estradiol | transforming growth factor beta 1 | Homo sapiens |
| 3 | 17-Beta-estradiol potently increases the migratory potency of MCF-7 cells, but inhibits TGF-beta-induced migration by an interaction between estrogen receptors and Smad proteins. | Estradiol | transforming growth factor beta 1 | Homo sapiens |