Title : Flunarizine is a highly potent inhibitor of cardiac hERG potassium current.

Pub. Date : 2006 Feb

PMID : 16495758






4 Functional Relationships(s)
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1 Flunarizine is a highly potent inhibitor of cardiac hERG potassium current. Potassium ETS transcription factor ERG Homo sapiens
2 We examined the effects of flunarizine on potassium currents through cardiac channels encoded by the human ether-a-go-go related gene (hERG) stably expressed in CHO cells. Potassium ETS transcription factor ERG Homo sapiens
3 In this study, we have characterized the effect of flunarizine on biophysical properties of hERG potassium currents with standard whole-cell voltage-clamp techniques. Potassium ETS transcription factor ERG Homo sapiens
4 The effect of flunarizine on hERG potassium current is concentration and time dependent, and displays voltage dependence over the voltage range between -40 and 0 mV. Potassium ETS transcription factor ERG Homo sapiens