Title : Functional expression of mammalian bitter taste receptors in Caenorhabditis elegans.

Pub. Date : 2006 Jul

PMID : 16494987






2 Functional Relationships(s)
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1 As a proof of the concept, we generated transgenic worms expressing human T2R4 or its mouse ortholog T2R8 receptors, which respond to two bitter tastants previously characterised as their functional ligands, 6-n-propyl-2-thiouracil and denatoniun. Propylthiouracil taste 2 receptor member 4 Homo sapiens
2 As expected, expression of human T2R4 or its mouse ortholog T2R8 in ASI neurons counteracted the water-soluble avoidance to 6-n-propyl-2-thiouracil and denatoniun observed in control wild-type worms. Propylthiouracil taste 2 receptor member 4 Homo sapiens