Title : Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha.

Pub. Date : 2006 May 26

PMID : 16492670






2 Functional Relationships(s)
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1 Treatment of mice with phenobarbital or TCPOBOP resulted in decreased hepatic mRNA levels of the reported genes down-regulated by CAR, including Cyp7a1 and Pepck. Phenobarbital cytochrome P450, family 7, subfamily a, polypeptide 1 Mus musculus
2 In vivo recruitment of endogenous CAR to the promoters of Cyp7a1 and Pepck was detected in mouse liver after phenobarbital treatment, whereas association of HNF-4 and coactivators, GRIP-1, p300, and PGC-1alpha, with these promoters was significantly decreased. Phenobarbital cytochrome P450, family 7, subfamily a, polypeptide 1 Mus musculus