Pub. Date : 2006 Apr
PMID : 16490780
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Establishment of a cell model based on FKBP12 dimerization for screening of FK506-like neurotrophic small molecular compounds. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 2 | In this present study, the authors constructed a stable cell line, which underwent apoptosis upon treatment by AP20187, a wholly synthesized, cell-permeable dimeric FK506 derivative, based on FKBP12-mBax dimerization. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 3 | This AP20187-mediated apoptosis was rapidly reversed by the addition of an FKBP12-binding competitor molecule (FK506 or rapamycin), indicating that this cell line might be used to screen FK506 derivatives. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 4 | This AP20187-mediated apoptosis was rapidly reversed by the addition of an FKBP12-binding competitor molecule (FK506 or rapamycin), indicating that this cell line might be used to screen FK506 derivatives. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |