Pub. Date : 2006 May
PMID : 16484285
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mono-(2-ethylhexyl) phthalate rapidly increases celsr2 protein phosphorylation in HeLa cells via protein kinase C and casein kinase 1. | mono-(2-ethylhexyl)phthalate | cadherin EGF LAG seven-pass G-type receptor 2 | Homo sapiens |
| 2 | Within 2 h of a 1-g/kg mono-(2-ethylhexyl) phthalate (MEHP) exposure, in vivo Sertoli cell celsr2 localization was altered; celsr2 immunostaining became concentrated in the basal aspect of Sertoli cells, and then a diffuse pattern emerged. | mono-(2-ethylhexyl)phthalate | cadherin EGF LAG seven-pass G-type receptor 2 | Homo sapiens |
| 3 | Within 2 h of a 1-g/kg mono-(2-ethylhexyl) phthalate (MEHP) exposure, in vivo Sertoli cell celsr2 localization was altered; celsr2 immunostaining became concentrated in the basal aspect of Sertoli cells, and then a diffuse pattern emerged. | mono-(2-ethylhexyl)phthalate | cadherin EGF LAG seven-pass G-type receptor 2 | Homo sapiens |
| 4 | Within 2 h of a 1-g/kg mono-(2-ethylhexyl) phthalate (MEHP) exposure, in vivo Sertoli cell celsr2 localization was altered; celsr2 immunostaining became concentrated in the basal aspect of Sertoli cells, and then a diffuse pattern emerged. | mono-(2-ethylhexyl)phthalate | cadherin EGF LAG seven-pass G-type receptor 2 | Homo sapiens |
| 5 | Within 2 h of a 1-g/kg mono-(2-ethylhexyl) phthalate (MEHP) exposure, in vivo Sertoli cell celsr2 localization was altered; celsr2 immunostaining became concentrated in the basal aspect of Sertoli cells, and then a diffuse pattern emerged. | mono-(2-ethylhexyl)phthalate | cadherin EGF LAG seven-pass G-type receptor 2 | Homo sapiens |
| 6 | Because GPCRs are regulated by phosphorylation, the hypothesis that phthalate exposure induces the phosphorylation of celsr2 was tested by examining phosphorylation in celsr2-transfected HeLa cells treated with MEHP. | mono-(2-ethylhexyl)phthalate | cadherin EGF LAG seven-pass G-type receptor 2 | Homo sapiens |
| 7 | At concentrations of 1 microM or greater, MEHP transiently increased celsr2 phosphorylation on serine/threonine residues; celsr2 phosphorylation was increased by 15 min of exposure and returned to control levels after 60 min. | mono-(2-ethylhexyl)phthalate | cadherin EGF LAG seven-pass G-type receptor 2 | Homo sapiens |
| 8 | Inhibition of protein kinase C or casein kinase 1 prevented MEHP-induced celsr2 phosphorylation, while inhibition of protein kinase A or mitogen-activated protein kinase had no effect. | mono-(2-ethylhexyl)phthalate | cadherin EGF LAG seven-pass G-type receptor 2 | Homo sapiens |