Pub. Date : 2006 Feb
PMID : 16483679
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A combined treatment TNF-alpha/doxorubicin alleviates the resistance of MCF-7/Adr cells to cytotoxic treatment. | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 2 | Treatment of cells with TNF-alpha following doxorubicin (DOX) resulted in a decrease of the activated Rel A/p65 in nuclei. | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 3 | Treatment of cells with TNF-alpha following doxorubicin (DOX) resulted in a decrease of the activated Rel A/p65 in nuclei. | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 4 | The combined treatment of TNF-alpha/DOX also resulted in a significant decrease of mRNA levels of anti-apoptotic genes, such as the cellular inhibitor of apoptosis-1 (c-IAP1), and the long isoform of B cell leukemia/lymphoma x gene (Bcl-xL), leading to efficient induction of caspase-8 cleavage and cell death. | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 5 | In previous work, we demonstrated that TNF-alpha promotes DOX-induced cell death and anti-cancer effect through downregulation of p21 in p53-deficient tumor cells. | Doxorubicin | tumor necrosis factor | Homo sapiens |