Title : Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells.

Pub. Date : 2006 Oct

PMID : 16463058






1 Functional Relationships(s)
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1 CONCLUSIONS: These results show that genetic modifications in non-hematological malignant cells may be associated with resistance to gemcitabine, and that the gene transfer of non-human genes can be used for the reversion of nucleoside analogue resistance due to dCK deficiency. Nucleosides Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster