Pub. Date : 2006 Mar 31
PMID : 16452467
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | UDP-galactose 4"-epimerase (GALE) catalyzes the final step of the highly conserved Leloir pathway of galactose metabolism. | Galactose | UDP-galactose-4-epimerase | Homo sapiens |
| 2 | Loss of GALE in yeast results in galactose-dependent growth arrest. | Galactose | UDP-galactose-4-epimerase | Homo sapiens |
| 3 | Although the role of GALE in galactose metabolism has been recognized for decades, the precise relationship between GALE activity and galactose sensitivity has remained unclear. | Galactose | UDP-galactose-4-epimerase | Homo sapiens |
| 4 | 1) Is GALE rate-limiting for galactose metabolism in yeast? | Galactose | UDP-galactose-4-epimerase | Homo sapiens |
| 5 | 2) What is the relationship between GALE activity and galactose-dependent growth arrest in yeast? | Galactose | UDP-galactose-4-epimerase | Homo sapiens |
| 6 | 3) What is the relationship between GALE activity and the abnormal accumulation of galactose metabolites in yeast? | Galactose | UDP-galactose-4-epimerase | Homo sapiens |
| 7 | Our results demonstrated a smooth linear relationship between galactose metabolism and GALE activity over a range from 0 to approximately 5% but a steep threshold relationship between growth rate in galactose and GALE activity over the same range. | Galactose | UDP-galactose-4-epimerase | Homo sapiens |
| 8 | Our results demonstrated a smooth linear relationship between galactose metabolism and GALE activity over a range from 0 to approximately 5% but a steep threshold relationship between growth rate in galactose and GALE activity over the same range. | Galactose | UDP-galactose-4-epimerase | Homo sapiens |
| 9 | The relationship between abnormal accumulation of metabolites and GALE activity was also linear over the range from 0 to approximately 5%, suggesting that if the abnormal accumulation of metabolites underlies galactose-dependent growth-arrest in GALE-impaired yeast, either the impact of individual metabolites must be synergistic and/or the threshold of sensitivity must be very steep. | Galactose | UDP-galactose-4-epimerase | Homo sapiens |
| 10 | The relationship between abnormal accumulation of metabolites and GALE activity was also linear over the range from 0 to approximately 5%, suggesting that if the abnormal accumulation of metabolites underlies galactose-dependent growth-arrest in GALE-impaired yeast, either the impact of individual metabolites must be synergistic and/or the threshold of sensitivity must be very steep. | Galactose | UDP-galactose-4-epimerase | Homo sapiens |