Title : Identification of amino acid substitutions that alter the substrate specificity of TEM-1 beta-lactamase.

Pub. Date : 1992 Aug

PMID : 1644749






2 Functional Relationships(s)
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1 To identify other amino acid substitutions that alter the activity of TEM-1 towards extended-spectrum cephalosporins, we probed regions around the active-site pocket by random-replacement mutagenesis. Cephalosporins CD248 molecule Homo sapiens
2 Substitutions at positions 104, 168, and 238 in the TEM-1 beta-lactamase that resulted in increased enzyme activity towards extended-spectrum cephalosporins were found. Cephalosporins CD248 molecule Homo sapiens