Title : Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters.

Pub. Date : 2006 Apr

PMID : 16434549






2 Functional Relationships(s)
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1 The objective of the current study was to examine the kinetics of amoxicillin and cefaclor interactions with human renal transporters human organic anion transporter 1 (hOAT1), human peptide transporter 1 (hPepT1), and human peptide transporter 2 (hPepT2) in detail, both as substrates and as inhibitors. Amoxicillin solute carrier family 22 member 6 Homo sapiens
2 Amoxicillin and cefaclor inhibited hOAT1-mediated [(3)H]para-aminohippuric acid uptake (K(i) = 11.0 and 1.15 mM, respectively). Amoxicillin solute carrier family 22 member 6 Homo sapiens