Title : Peripheral inflammation modifies the effect of intrathecal IL-1beta on spinal PGE2 production mainly through cyclooxygenase-2 activity. A spinal microdialysis study in freely moving rats.

Pub. Date : 2006 Feb

PMID : 16427196






4 Functional Relationships(s)
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1 Peripheral inflammation modifies the effect of intrathecal IL-1beta on spinal PGE2 production mainly through cyclooxygenase-2 activity. Dinoprostone interleukin 1 beta Rattus norvegicus
2 The possible involvement of cyclooxygenase (COX) isoforms in the IL-1beta-mediated spinal PGE(2) production on the background of peripheral formalin inflammation was further evaluated with the selective COX-1 and COX-2 inhibitors. Dinoprostone interleukin 1 beta Rattus norvegicus
3 administration of IL-1beta, with doses of 1, 2, 8, or 16 ng, increased PGE(2) levels in CSF in a dose-related fashion. Dinoprostone interleukin 1 beta Rattus norvegicus
4 Peripheral formalin inflammation in the paw induced a more prolonged effect of spinal IL-1beta with larger PGE(2) releases in the CSF compared with the non-inflammatory state, suggesting that peripheral inflammation enhances central sensitization. Dinoprostone interleukin 1 beta Rattus norvegicus