Pub. Date : 2006 Feb
PMID : 16427196
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | IL-1beta on spinal PGE(2) production in the absence and presence of peripheral formalin inflammation with spinal microdialysis in freely moving rats. | Prostaglandins E | interleukin 1 beta | Rattus norvegicus |
2 | The COX-2 inhibitor SC58236 (15 mg/kg) reduced the IL-1beta-mediated PGE(2) increase in CSF by 86% while the COX-1 inhibitor SC58560 (15 mg/kg) had less effect (28%). | Prostaglandins E | interleukin 1 beta | Rattus norvegicus |
3 | Our study suggests that mainly the COX-2 enzyme mediates the IL-1beta-induced increase in spinal PGE(2) in the presence of peripheral formalin inflammation. | Prostaglandins E | interleukin 1 beta | Rattus norvegicus |