Title : Peripheral inflammation modifies the effect of intrathecal IL-1beta on spinal PGE2 production mainly through cyclooxygenase-2 activity. A spinal microdialysis study in freely moving rats.

Pub. Date : 2006 Feb

PMID : 16427196






3 Functional Relationships(s)
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1 IL-1beta on spinal PGE(2) production in the absence and presence of peripheral formalin inflammation with spinal microdialysis in freely moving rats. Prostaglandins E interleukin 1 beta Rattus norvegicus
2 The COX-2 inhibitor SC58236 (15 mg/kg) reduced the IL-1beta-mediated PGE(2) increase in CSF by 86% while the COX-1 inhibitor SC58560 (15 mg/kg) had less effect (28%). Prostaglandins E interleukin 1 beta Rattus norvegicus
3 Our study suggests that mainly the COX-2 enzyme mediates the IL-1beta-induced increase in spinal PGE(2) in the presence of peripheral formalin inflammation. Prostaglandins E interleukin 1 beta Rattus norvegicus