Title : Target structure-based discovery of small molecules that block human p53 and CREB binding protein association.

Pub. Date : 2006 Jan

PMID : 16426974






1 Functional Relationships(s)
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1 Here, we report small molecules that block lysine 382-acetylated p53 association with the bromodomain of the coactivator CBP, an interaction essential for p53-induced transcription of the cell cycle inhibitor p21 in response to DNA damage. Lysine H3 histone pseudogene 16 Homo sapiens