Title : Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway.

Pub. Date : 2006 Apr

PMID : 16425058






1 Functional Relationships(s)
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1 RATIONALE: Sildenafil citrate is widely prescribed for erectile dysfunction and acts by inhibiting phosphodiesterase type-5, resulting in accumulation of cyclic-guanosine monophosphate (cGMP) via activation of nitric oxide synthase (NOS). Sildenafil Citrate nitric oxide synthase 1, neuronal Mus musculus