Pub. Date : 2006
PMID : 16424655
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib. | Bortezomib | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 2 | FK228-induced apoptosis and mitochondrial translocation of Bax were markedly enhanced by the proteasome inhibitor bortezomib. | Bortezomib | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 3 | The synergistic action of FK228 and bortezomib was at least partly mediated through conformational changes in Bax, which facilitate its translocation to the mitochondria. | Bortezomib | BCL2 associated X, apoptosis regulator | Homo sapiens |