Title : Intraperitoneal administration of recombinant human interleukin-1 beta inhibits osmotic thirst in the rat.

Pub. Date : 1992 Jun

PMID : 1641429






5 Functional Relationships(s)
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1 Decrease in water intake after intraperitoneal injection of interleukin-1 beta (IL-1 beta) was studied in the rat. Water interleukin 1 beta Rattus norvegicus
2 Decrease in water intake after intraperitoneal injection of interleukin-1 beta (IL-1 beta) was studied in the rat. Water interleukin 1 beta Rattus norvegicus
3 Interleukin-1 beta also decreased spontaneous intake of water but not that of 1.8% saline. Water interleukin 1 beta Rattus norvegicus
4 The results suggest that the decrease in water intake by IL-1 beta is caused, at least in part, by suppression of osmotic thirst but not by general suppression of behavior. Water interleukin 1 beta Rattus norvegicus
5 Pretreatment with indomethacin blocked the decrease in water intake by IL-1 beta, suggesting the involvement of production of prostaglandins. Water interleukin 1 beta Rattus norvegicus