Title : 15-Deoxy-Delta(12,14)-prostaglandin J(2) suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells.

Pub. Date : 2006 May 22

PMID : 16413037






3 Functional Relationships(s)
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1 Among the antioxidants, only NAC and glutathione reversed the effects of 15d-PGJ(2). 15d-pgj X-linked Kx blood group Homo sapiens
2 NAC, glutathione and DTT all reversed the inhibition of STAT3 phosphorylation when preincubated with 15d-PGJ(2). 15d-pgj X-linked Kx blood group Homo sapiens
3 The inhibition of ICAM-1 gene expression by 15d-PGJ(2) was abrogated by NAC and glutathione in IL-6-treated ECs. 15d-pgj X-linked Kx blood group Homo sapiens