Title : Intracellular acidification delays hormonal G2/M transition and inhibits G2/M transition triggered by thiophosphorylated MAPK in Xenopus oocytes.

Pub. Date : 2006 May 15

PMID : 16408274






2 Functional Relationships(s)
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1 Cyclin B2 phosphorylation, Cdk1 Tyr15 dephosphorylation as well as p39(Mos) accumulation, Xp42(Mpk1) and p90(Rsk) phosphorylation induced by progesterone were also delayed by incubation of oocyte in NH(4)Cl. Progesterone cyclin-dependent kinase 1 L homeolog Xenopus laevis
2 Taken together, our results suggest that dynamic of early events driving Xp42(Mpk1) and MPF activation induced by progesterone may be negatively or positively regulated by pH(i) changes. Progesterone cyclin-dependent kinase 1 L homeolog Xenopus laevis