Title : CCAAT/enhancer binding protein activation by PD98059 contributes to the inhibition of AhR-mediated 3-methylcholanthrene induction of CYP1A1.

Pub. Date : 2005 Oct-Nov

PMID : 16393856






5 Functional Relationships(s)
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1 PD98059 treatment inhibited 3-MC-induced AhR binding to the XRE, but increased protein binding to the CYP1A1 C/EBP binding site. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one CCAAT enhancer binding protein alpha Homo sapiens
2 The role of C/EBP activation by PD98059 in repressing CYP1A1 induction was supported by the observation that a dominant-negative mutant C/EBP abolished the ability of PD98059 to suppress 3-MC induction of CYP1A1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one CCAAT enhancer binding protein alpha Homo sapiens
3 The role of C/EBP activation by PD98059 in repressing CYP1A1 induction was supported by the observation that a dominant-negative mutant C/EBP abolished the ability of PD98059 to suppress 3-MC induction of CYP1A1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one CCAAT enhancer binding protein alpha Homo sapiens
4 The role of C/EBP activation by PD98059 in repressing CYP1A1 induction was supported by the observation that a dominant-negative mutant C/EBP abolished the ability of PD98059 to suppress 3-MC induction of CYP1A1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one CCAAT enhancer binding protein alpha Homo sapiens
5 The role of C/EBP activation by PD98059 in repressing CYP1A1 induction was supported by the observation that a dominant-negative mutant C/EBP abolished the ability of PD98059 to suppress 3-MC induction of CYP1A1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one CCAAT enhancer binding protein alpha Homo sapiens