Pub. Date : 2006 Feb
PMID : 16391787
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this report, we demonstrate that estradiol and nicotine exposure enhances the growth of A549 bronchioloalveolar carcinoma xenografts in mice through the stimulation of cell proliferation, VEGF secretion and angiogenesis. | Nicotine | vascular endothelial growth factor A | Mus musculus |
| 2 | Furthermore, estradiol promotes VEGF secretion from various non-small cell lung carcinoma (NSCLC) cells and this effect is augmented by nicotine in a tumor xenograft model. | Nicotine | vascular endothelial growth factor A | Mus musculus |
| 3 | These results indicate that aside from their roles in promoting cell proliferation, estradiol and nicotine appear to have additive effects on the induction of angiogenesis through the stimulation of VEGF secretion during NSCLC progression. | Nicotine | vascular endothelial growth factor A | Mus musculus |