Title : Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells.

Pub. Date : 2006 Mar

PMID : 16385087






3 Functional Relationships(s)
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1 METHODS AND RESULTS: Metformin dose-dependently inhibited IL-1beta-induced release of the pro-inflammatory cytokines IL-6 and IL-8 in ECs, SMCs, and Mphis. Metformin interleukin 1 beta Homo sapiens
2 Investigation of potential signaling pathways demonstrated that metformin diminished IL-1beta-induced activation and nuclear translocation of nuclear factor-kappa B (NF-kappaB) in SMCs. Metformin interleukin 1 beta Homo sapiens
3 Furthermore, metformin suppressed IL-1beta-induced activation of the pro-inflammatory phosphokinases Akt, p38, and Erk, but did not affect PI3 kinase (PI3K) activity. Metformin interleukin 1 beta Homo sapiens