Title : NFAT regulates calcium-sensing receptor-mediated TNF production.

Pub. Date : 2006 May

PMID : 16380462






3 Functional Relationships(s)
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1 Activation of the CaR also increased the binding of NFAT to a consensus oligonucleotide, an effect that was blocked by U-73122 and CsA, suggesting that a calcineurin- and NFAT-dependent pathway increases TNF production in mTAL cells. Cyclosporine tumor necrosis factor Homo sapiens
2 This mechanism likely regulates TNF gene transcription as U-73122, CsA, and VIVIT blocked CaR-dependent activity of a TNF promoter construct. Cyclosporine tumor necrosis factor Homo sapiens
3 This mechanism likely regulates TNF gene transcription as U-73122, CsA, and VIVIT blocked CaR-dependent activity of a TNF promoter construct. Cyclosporine tumor necrosis factor Homo sapiens