Title : In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug.

Pub. Date : 2006 Jan

PMID : 16379042






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 ET-743 showed the highest affinity for CYP3A4 and the highest maximal metabolic rate for CYP2D6 among the CYPs shown to metabolize ET-743. Trabectedin cytochrome P450 family 2 subfamily D member 6 Homo sapiens
2 ET-743 showed the highest affinity for CYP3A4 and the highest maximal metabolic rate for CYP2D6 among the CYPs shown to metabolize ET-743. Trabectedin cytochrome P450 family 2 subfamily D member 6 Homo sapiens