Title : Chronic hypoxia-enhanced murine pulmonary vasoconstriction: role of superoxide and gp91phox.

Pub. Date : 2005 Dec

PMID : 16373854






1 Functional Relationships(s)
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1 Using mice that are completely deficient in gp91phox (a subunit protein of the superoxide producing nicotinamide adenine dinucleotide phosphate [NADPH] oxidase), we found that CH-enhanced PA constriction to ET-1 was completely blocked (decreases in mean [+/- SE] maximal isometric tension from 5.43 +/- 0.35 to 3.33 +/- 0.19 mN; n = 7; p < 0.01). NAD cytochrome b-245, beta polypeptide Mus musculus