Title : Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma.

Pub. Date : 2006 Feb 17

PMID : 16365037






4 Functional Relationships(s)
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Protein Name
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1 Methenyltetrahydrofolate synthetase (MTHFS) is the only enzyme that metabolizes 5-formylTHF and catalyzes its ATP-dependent conversion to 5,10-methenylTHF. Leucovorin methenyltetrahydrofolate synthetase Homo sapiens
2 Methenyltetrahydrofolate synthetase (MTHFS) is the only enzyme that metabolizes 5-formylTHF and catalyzes its ATP-dependent conversion to 5,10-methenylTHF. Leucovorin methenyltetrahydrofolate synthetase Homo sapiens
3 Feedback metabolic regulation of MTHFS by 10-formylTHF indicates that 5-formylTHF can only accumulate in the presence of 10-formylTHF, providing the first evidence that 5-formylTHF is a storage form of excess formylated folates in mammalian cells. Leucovorin methenyltetrahydrofolate synthetase Homo sapiens
4 Feedback metabolic regulation of MTHFS by 10-formylTHF indicates that 5-formylTHF can only accumulate in the presence of 10-formylTHF, providing the first evidence that 5-formylTHF is a storage form of excess formylated folates in mammalian cells. Leucovorin methenyltetrahydrofolate synthetase Homo sapiens