Title : Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2.

Pub. Date : 2006 Apr

PMID : 16360206






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Proteins that bear immunoreceptor tyrosine based inhibitory motifs (ITIM) are believed to participate in the repression of cell activation via phosphatases such as SHP-1, SHP-2 and/or SHIP-1. Tyrosine protein tyrosine phosphatase non-receptor type 6 Homo sapiens