Title : Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses.

Pub. Date : 2006 Apr 15

PMID : 16357326






2 Functional Relationships(s)
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1 PGE2 stimulated the accumulation of cyclic adenosine monophosphate (cAMP), and suppressed both Fc epsilonRI-mediated eicosanoid production and tumor necrosis factor-alpha (TNF-alpha) generation. Eicosanoids Fc epsilon receptor Ia Homo sapiens
2 Thus, while PGE2 activates MCs through EP3 receptors, it also counteracts Fc epsilonRI-mediated eicosanoid production through EP2 receptors and PKA, and blocks cytokine transcription. Eicosanoids Fc epsilon receptor Ia Homo sapiens