Pub. Date : 2005 Nov
PMID : 16324248
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The dose- and time-related effect of estradiol benzoate and ICI 182780 on the cell growth was measured by mononuclear cell direct cytotoxicity assay (methyl thiazolyl tetrazolium assay), and that on the expression of HSP70 and HSP90 in normal endometrial glandular epithelial cell in vitro was measured by immunohistochemical analysis and computerized image analysis system. | estradiol 3-benzoate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | Estradiol benzoate treatment resulted in a time- and dose-dependent increase of the expression of HSP90 and decrease of HSP70 in human endometrial glandular epithelial cell. | estradiol 3-benzoate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | The expression of HSP90 in 10(-9), 10(-8), 10(-7), 10(-6) mol/L estradiol benzoate for 24 hours were (64.8 +/- 10.7)%, (75.9 +/- 12.6)%, (80.4 +/- 8.2)%, (83.2 +/- 7.6)%, which were significantly higher than that of the control [(28.0 +/- 3.3)%, (29.0 +/- 5.6)%, (29.0 +/- 5.0)%, (30.0 +/- 6.4)%, P < 0.05] and that of estradiol benzoate + ICI 182780 for 24 hours [(28.2 +/- 2.1)%, (29.7 +/- 3.2)%, (35.0 +/- 4.7)%, (34.7 +/- 6.5)%, P < 0.05]. | estradiol 3-benzoate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | The expression of HSP90 in 10(-9), 10(-8), 10(-7), 10(-6) mol/L estradiol benzoate for 24 hours were (64.8 +/- 10.7)%, (75.9 +/- 12.6)%, (80.4 +/- 8.2)%, (83.2 +/- 7.6)%, which were significantly higher than that of the control [(28.0 +/- 3.3)%, (29.0 +/- 5.6)%, (29.0 +/- 5.0)%, (30.0 +/- 6.4)%, P < 0.05] and that of estradiol benzoate + ICI 182780 for 24 hours [(28.2 +/- 2.1)%, (29.7 +/- 3.2)%, (35.0 +/- 4.7)%, (34.7 +/- 6.5)%, P < 0.05]. | estradiol 3-benzoate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 5 | CONCLUSIONS: The effects of estradiol benzoate on the cell growth and HSP90 expression are estrogen receptor-dependent and the expression of HSP90 may be beneficial to the cell growth. | estradiol 3-benzoate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 6 | CONCLUSIONS: The effects of estradiol benzoate on the cell growth and HSP90 expression are estrogen receptor-dependent and the expression of HSP90 may be beneficial to the cell growth. | estradiol 3-benzoate | heat shock protein 90 alpha family class A member 1 | Homo sapiens |