Title : Alcohol increases tumor necrosis factor alpha and decreases nuclear factor-kappab to activate hepatic apoptosis in genetically obese mice.

Pub. Date : 2005 Dec

PMID : 16317704






1 Functional Relationships(s)
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1 Alcohol administration to ob/ob mice did not increase oxidative stress despite increased CYP2E1, but increased plasma TNF-alpha, further increased Hsp70, and profoundly decreased p65 nuclear factor kappaB (NF-kappaB) protein and DNA-binding activity in nuclear extracts. Alcohols cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus