Title : Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1.

Pub. Date : 2006 Mar

PMID : 16306078






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In the human adrenal cortex, ACTH activates steroid hormone biosynthesis by acutely increasing cholesterol delivery to the mitochondrion and chronically increasing the transcription of steroidogenic genes (including CYP17) via a cAMP-dependent pathway. Cholesterol proopiomelanocortin Homo sapiens