Title : Mitochondrial thymidine kinase inhibitors.

Pub. Date : 2005

PMID : 16305527






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Several recent investigations point to an important role of TK-2 in the maintenance of mitochondrial dNTPs pools. Parathion thymidine kinase 2 Homo sapiens
2 In this scenario, TK-2 inhibitors could be a useful tool to further clarify both the physiological role of TK-2 in the maintenance of mitochondrial dNTP pools, and the possible contribution of TK-2 to the mitochondrial toxicity of pyrimidine nucleoside analogues. Parathion thymidine kinase 2 Homo sapiens
3 In this scenario, TK-2 inhibitors could be a useful tool to further clarify both the physiological role of TK-2 in the maintenance of mitochondrial dNTP pools, and the possible contribution of TK-2 to the mitochondrial toxicity of pyrimidine nucleoside analogues. Parathion thymidine kinase 2 Homo sapiens
4 In this scenario, TK-2 inhibitors could be a useful tool to further clarify both the physiological role of TK-2 in the maintenance of mitochondrial dNTP pools, and the possible contribution of TK-2 to the mitochondrial toxicity of pyrimidine nucleoside analogues. Parathion thymidine kinase 2 Homo sapiens